Metformin helps us control our weight, insulin levels – and it fights the Covid-19 virus!
Metformin is based on a natural herb called French Lilac,
also called Goat’s Rue or Gallega officinalis
Who was to know that Metformin, a tried and trusted drug that is used to treat insulin resistance was originally developed to fight the flu in the 1920’s? They discovered an unexpected side effect – that of lowering blood sugar levels. A new drug was thus launched and the vast majority of diabetics still use it today. A comparative reduction in the rate of mortality in diabetic patients on Metformin with severe SARS-CoV-2 has been observed according to four hospital studies that show lower instances of death in their patients who take Metformin.
According to other studies, Metformin has demonstrated the potential to directly inhibit the SARS-CoV-2 infection. This is excellent news, especially in the light of trying to establish (and promulgate) a vaccine for one of an ever-mutating family of coronaviruses. A drug like Metformin /Glucophage is based on the molecular components (or actives) of a plant called French Lilac or Goat’s Rue. This remedy has a good safety profile, kills parasites as well as viruses and bacteria. Yet unlike other antibiotics, it is beneficial to the gut microbiome in a number of ways. It alters the bacterial strains to improve insulin sensitivity and the uptake of short chain fatty acids. This helps to reduce inflammation and prevent gut permeability. It is not yet clearly understood how it is able to enhance the growth of some bacteria in order to benefit the host. Goat’s Rue in its original form is also available as a health supplement and the recommended dose on most products is a 500mg capsule. Like Metformin, it is recommended for lowering blood glucose and for weight loss.
There seems to be a link between insulin resistance and the severity of SARS-CoV-2 infections. We are familiar with older people who have cardiovascular problems, inflammation, elevated blood sugar, metabolic disorders and other debilitating conditions that require chronic medications. Such coronavirus patients (including SARS-CoV-2) who are unable to control high glucose levels in their bloodstream are more prone to hyper inflammation, vasoconstriction and blood clots.
We hear a lot about angiotensin 2 enzyme (ACE2) receptors that are present on the spikes of all coronaviruses. Coronaviruses use these extrusions to bind to their target cells. But normally, these receptors are used for controlling inflammation with the enzyme we call ACE2. They degrade angiotensin 2 into angiotensin 1–7 (ACE 1-7) to reduce insulin resistance by decreasing cellular oxidative stress, enhancing insulin signalling and insulin-stimulated glucose transport activity. It reduces inflammation as well as vasoconstriction and blood clotting. ACE2 is expressed in tissues that include lung alveolar epithelial cells, pancreatic beta cells and enterocytes of the small intestine to ward of the ravages of inflammation that we call a cytokine storm, linked to the renin-angiotensin-aldosterone system (RAAS) that drives insulin resistance and cardiovascular problems.
Metformin can lower blood sugar by preventing the liver from producing too much of it. Lowering blood sugar also enables vitamin C to directly access receptor sites that glucose competes with. Less sugar = less inflammation. Metformin restricts the growth of Pseudomonas Aeruginosa – a nasty bacterium within the lungs. Recent studies have shown that larger parasites like Trypanosoma Cruzi and Trichinella Spiralis are also killed off. Larger parasites, especially eggs and larvae that migrate to the brain, heart and lungs can cause a lot of inflammation. that complicate Covid-19 outbreaks in countries like China, Italy, Spain, Mexico and Brazil where a lot of meat, especially pork is consumed. Consuming raw or undercooked meat poses a greater risk for infections. Hyper inflammation can lead to sepsis (blood vessel and organ damage) and here too, Metformin helps to decrease the pro-inflammatory cytokine load.
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